By Christopher D Byrne; Sarah H Wild
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Lisboa, H. , Tres, G. , Gross, J. L. 2004. Aggregation of features of the metabolic syndrome is associated with increased prevalence of chronic complications in type 2 diabetes. Diabet. , 21 (3), 252–255. , Tauber, J. , Amouyel, P. 2004. The association of metabolic disorders with the metabolic syndrome is different in men and women. Ann. Nutr. , 48 (1), 43–50. Diez, J. , Iglesias, P. 2003. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur. J. , 148 (3), 293–300.
Although to date there is no central unifying mechanism that explains all of the features of the syndrome, it is most likely that certain of the features occur as secondary consequences of a primary abnormality (or several primary abnormalities). 9 Preoalence (%) 170 453 19 934 13 225 7118 22 273 20 709 31 570 11 610 44 016 No. 3 Estimated prevalence and number of people 20+ years of age with the metabolic syndrome and diabetes by region for 2000 (see text for details of methods) Pathogenesis of the metabolic syndrome 21 syndrome, an understanding of the cause and consequences of insulin resistance is crucial to an understanding of the pathogenesis of the metabolic syndrome.
Similarly, populations with a higher prevalence of type 2 diabetes are likely to have a higher prevalence of the metabolic syndrome in the whole population than those with lower prevalence of type 2 diabetes. Pathogenesis of the metabolic syndrome 19 Confounding Potential confounding factors between certain population characteristics, such as age, gender, obesity and co-morbidity, and the prevalence of the metabolic syndrome are considered above. Some prevalence studies have not considered potential confounding factors, and even among those that have considered these factors there remains the potential for residual confounding.
The metabolic syndrome by Christopher D Byrne; Sarah H Wild