By Koichi Tanaka
Chemical Synthesis with out using solvents has built right into a strong technique because it reduces the volume of poisonous waste produced and as a result turns into much less damaging to the surroundings.
Koichi Tanaka discusses the most recent advancements during this box, giving emphasis at the expertise used in addition to the sensible applications.
- The ebook handles either conception and alertness of this box
- Includes guideline at the new applied sciences getting used
- Valuable info to method chemists in undefined, in addition to lecturers and students
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Additional info for Solvent-free Organic Synthesis opt
Pure product is obtained by distillation under reduced pressure in 65–90% yields. References: B. , 41, 3169 (2000); H. Firouzabadi, N. Iranpoor, S. Sobhani, A. , 42, 4369 (2001). 1 Solvent-Free Oxidation 21 Experimental procedures: PCC (3–15 mmol) was added to the substrate (3 mmol) in a mortar. Starting materials were instantly mixed and then stored for the appropriate period at room temperature or in an microwave oven without any further agitation. The progress of the reaction was monitored by dissolving a sample in acetone and using TLC on silica gel (hexane-Et2O, 3:1).
The crude product was subjected to column chromatography using hexane-EtOAc (8 : 2) as eluent affording the corresponding carbonyl compound. References: M. M. Heravi, D. Ajami, K. Tabar-Hydar, M. Ghassemzadeh, J. Chem. Res. (S), 334 (1999). 85 mmol of CuSO4 · 5H2O) were mixed thoroughly on a vortex mixer. The reaction mixture contained in glass tubes was placed in an alumina bath (heat sink) inside the microwave oven and irradiated for a specified time. On completion of the reaction, followed by TLC examination (hexane-ethyl acetate, 9:1), the product was extracted into methylene chloride (3 ´ 10 mL).
31, 2563 (2001). 4 mmol of KOH was ground in an agate mortar. After 20–30 min, the color of the mixture turned orange-yellow, orange or dark green. Then 20 mL of water was added, then yellow, orange and orange-red and dark green products were precipitated. The product was isolated by filtration, and washed with water four times. The products were recrystallized from a mixture of ethanol and water, and dried under vacuum. Structures of these products were characterized by elemental analysis, IR and 1H NMR spectroscopy.
Solvent-free Organic Synthesis opt by Koichi Tanaka