Download e-book for kindle: Neurotoxins by P. Michael Conn (Eds.)

By P. Michael Conn (Eds.)

ISBN-10: 0121852652

ISBN-13: 9780121852658

ISBN-10: 0121852660

ISBN-13: 9780121852665

The beautiful simplicity and efficiency of poisons have made them invaluable probes of neural structures. This publication offers a complete compilation of concepts used for the education, dealing with, and, rather, for using neurotoxins. version structures are defined within which those neurotoxins were super beneficial in constructing an realizing of the mobile and molecular foundation of secretion and electrophysiological occasions resulting in altered mobilephone functionality.

Key Features
* handy benchtop format
* tools offered for simple variation to new systems
* A digital ''A-B-C'' of well-known and to be had toxins
* accomplished protocols incorporated for using alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; ordinary pollutants; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins

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Example text

Specific binding is obtained by subtracting the nonspecific binding obtained in parallel reactions, containing 300 ixM veratridine or 500 /xM aconitine from the total binding. Specific binding ranges from 77 to 8 6 % of total binding. Protein concentrations in the vesicular preparation can b e determined by the m e t h o d of either Peterson (27) or L o w r y et al. (28). In the latter c a s e , the vesicular preparation must b e centrifuged and w a s h e d with phosphate-buffered saline (PBS) in order to r e m o v e the H E P E S / T r i s .

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Lucchesi, and A. Ravindran, J. Membr. Biol. 105, 95 (1988). 2. N. A. Castle, D. G. Haylett, and D. H. Jenkinson, Trends Pharmacol. Sci. 12, 59 (1989). 3. P. N. Strong, Pharmacol. Ther. 46, 137 (1990). 4. J. Gauldie, J. M. Hanson, R. A. Shipolini, and C. A. Vernon, Eur. J. Biochem. 83, 40 (1976). 5. B. E. C. Banks, C. E. Dempsey, F. Pearce, C. A. Vernon, and T. E. Wholley, Anal. Biochem. 116, 48 (1981). 24 NEUROTOXINS 6. E. M. Dotimas, R. C. Hider, U. Ragnarsson, and A. S. Tatham, Proc. Eur. Pept.

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