By Gerardo Caruso, Maria Caffo, Giuseppe Raudino, Francesco Tomasello
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Title: Nanoparticles and mind Tumor Treatment
Author: Caruso, Gerardo, M.D./ Caffo, Maria, Ph.D., M.D./ Raudino, Giuseppe, M.D./ Tomasello, Francesco, M.
Publisher: Amer Society of Mechanical
Publication Date: 2012/10/12
Number of Pages: 99
Binding sort: HARDCOVER
Library of Congress:
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It is one of the potent anticancer agent but less useful for clinical administration due to its poor solubility. PLGA intermingled with vitamin E, and tocopheryl polyethylene glycol succinate (TPGS) has been used to encapsulate this drug. This formulation has shown good activity, and a much faster administration in comparison to traditional formulation. Using some additive with the PLGA-NPs, 100% drug encapsulation efficiency was achieved with full antitumor activity . Cisplatin is a valid anticancer drug, but the full therapeutic exploitation of cisplatin is limited due to its toxicity in healthy tissues.
This is the case for CD47, a transmembrane protein that acts like a marker of the “self ” by binding to its cognate receptor expressed on leukocytes. CD47 inhibits phagocytosis, in part via regulation of the cytoskeleton and inhibition of engulfing structures. Incorporation of CD47 on drug carrier surfaces reduces attachment to neutrophils and macrophages, therefore prolonging circulation and inhibiting inflammation . In addition nanocarriers can also improve control of the drug efficacy upon release in the case of therapeutic interventions where the administration is local.
Initial results in nanotechnology-enabled molecular imaging have been made in all imaging modalities, including optical, nuclear, ultrasound, computed tomography, and magnetic resonance imaging (MRI). MRI contrast agents have made a significant impact in the use of MRI for various clinical indications. MRI contrast agents contain paramagnetic or superparamagnetic metal ions that affect the MRI signal properties of surrounding tissue. These contrast agents are used primarily to increase the sensitivity of MRI for detecting various pathological processes and also for characterizing various pathologies.
Nanoparticles and Brain Tumor Treatment by Gerardo Caruso, Maria Caffo, Giuseppe Raudino, Francesco Tomasello