Molecular Biology of Circadian Rhythms - download pdf or read online

By Amita Sehgal

ISBN-10: 0471418242

ISBN-13: 9780471418245

Sleek molecular biology and genetics has enabled major strides in study at the easy homes of organic rhythms. those advances will, as well as relevance for realizing of mobile and physique biochemistry, healthiness, and getting older, supply insights into the molecular regulate of habit. This complete account of the molecular foundation of circadian rhythms will disguise the hot advances as well as supplying a pretty good foundation within the uncomplicated points of organic timing.

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6a), per mRNA levels did not oscillate in a circadian manner and were expressed at levels approximating the median of the wild-type cycle. Even more striking were the effects on PER protein. The levels of PER detected by immunoblot analysis were constitutively low—equivalent to the levels found at the trough of the wild-type cycle. So the presence of TIM somehow stabilized PER in the wildtype flies. Additional insight was gained by examining the effects of the tim0 mutation on reporter transgenes, in which bacterial b-galactosidase was fused to the first half of per and expressed under the control of the per promoter.

1b). Superficially, these records resemble the sleep/wake records of mammals. It has been shown that the Drosophila activity rhythm has more than just a superficial resemblance to human sleep–wake cycles. Drosophila rest is associated with prolonged immobility, a characteristic posture, and unresponsiveness to sensory stimuli, as is mammalian sleep. Another similarity is that flies respond homeostatically to disrupted rest with an increased tendency to rest. This response is affected by several clock mutations.

Reprinted from Zeng et al. (1994): Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling. EMBO J 13(15): 3590–3598 by permission of Oxford University Press]. (b) Transgenic reporter genes driven by the per promoter were introduced into flies expressing wild-type PER. The levels of the BS-CAT reporter mRNA, which does not contain any per mRNA sequences but does contain the promoter regions that are responsive to transcriptional regulation, oscillate with a circadian rhythm that differs from the oscillation of per mRNA, while a BG-luc reporter mRNA containing the 5¢ part of the per mRNA oscillates in phase with per mRNA, presumably because it is regulated both transcriptionally and posttranscriptionally.

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Molecular Biology of Circadian Rhythms by Amita Sehgal

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