Mechanisms of Cell Toxicity by E. Edward Bittar (Eds.) PDF

By E. Edward Bittar (Eds.)

ISBN-10: 0762301414

ISBN-13: 9780762301416

Mobilephone biology is a speedily constructing self-discipline which brings jointly a few of the branches of the organic sciences that have been separate long ago. the 20 th century has witnessed the advance of a tremendous and numerous diversity of instruments and strategies (physical, chemical and organic) that have irrevocably replaced the research of phone biology, making it go barriers, hyperlink the molecule with the organelle and the mobile reaction with the bigger organism. those interrelations among mobile constitution and serve as on the molecular and subcellular point are the principal connecting topic of this sequence. This quantity takes for its topic the topic of phone toxicity starting with a viewpoint on intercellular objectives and together with chapters at the cytoskeleton, the function of mitochondria and xenobiotic metabolism

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Extra resources for Mechanisms of Cell Toxicity

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The dose and duration of ROS exposure is also critical in terms of the cytotoxic mechanisms involved, particularly with regard to the final outcome of exposure in terms of cell survival, metabolically and genetically intact or modified, or the mode of cell death (necrosis vs. apoptosis). Naturally, in v i m studies are useful but it can prove difficult to extrapolate these studies to in vivo. Several factors need to be considered when comparing in vitro model systems of ROS-induced cytotoxicity with the events occurring in vivo.

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