Download PDF by Doriano Fabbro, Sandra W. Cowan-Jacob, Henrik Möbitz: Kinase Inhibitors: Methods and Protocols

By Doriano Fabbro, Sandra W. Cowan-Jacob, Henrik Möbitz (auth.), Bernhard Kuster (eds.)

ISBN-10: 1617793361

ISBN-13: 9781617793363

ISBN-10: 161779337X

ISBN-13: 9781617793370

Protein and lipid kinases are usually the grasp regulators of telephone signaling in eukaryotic platforms. The human genome codes for greater than 500 of those enzymes and their misregulation has been proven to be occupied with the onset and development of many ailments together with melanoma and irritation. consequently, small molecule kinase inhibitors became very important learn instruments for the elucidation of the numerous organic roles of kinases and their mechanisms of motion. Kinase inhibitors hence additionally give a contribution considerably to the drug pipelines of the pharmaceutical and biotechnology industries and to the growing to be have to deal with melanoma and irritation. In Kinase Inhibitors: tools and Protocols, specialists in kinase biology, drug discovery, and scientific study current a chain of exemplary equipment that may be used to handle the numerous demanding situations dealing with scientists within the discovery and improvement of kinase inhibitors either for learn and scientific use. Written within the hugely winning Methods in Molecular Biology™ sequence structure, chapters comprise introductions to their respective themes, lists of the mandatory fabrics and reagents, step by step, conveniently reproducible laboratory protocols, and notes on troubleshooting and averting recognized pitfalls.

Authoritative and obtainable, Kinase Inhibitors: tools and Protocols aims to supply scientists with sleek and correct easy methods to speed up or boost their learn and drug discovery courses during the usage of those very important regulators.

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STKE 2004, pe12. 129. Dancey, J. , and Chen, H. X. (2006) Strategies for optimizing combinations of molecularly targeted anticancer agents, Nat. Rev. Drug. Discov. 5, 649–659. 130. , Krause, D. , and Van Etten, R. A. (2007) Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition, Nat. Rev. Cancer. 7, 332–344. 131. Olaharski, A. , and Kolaja, K. (2009) Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors, PLoS Comput. Biol. 5, e1000446.

And Varmus, H. (2005) Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain, PLoS Med. 2, e73. 25. Sawyers, C. (2004) Targeted cancer therapy, Nature 432, 294–297. 26. , Kim, H. , Lauffenburger, D. , and White, F. M. (2006) Effects of HER2 overexpression on cell signaling networks governing proliferation and migration, Mol Syst Biol 2, 54. 27. Heinrich, M. , Corless, C. , Demetri, G. , Blanke, C. , McGreevey, L. , Chen, C.

And Shewchuk, L. (2004) A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells, Cancer Res. 64, 6652–6659. 107. , and Kuriyan, J. (1999) Crystal structure of Hck in complex with a Src familyselective tyrosine kinase inhibitor, Mol. Cell 3, 639–648. 108. Levinson, N. , Young, M. , Cole, P. , and Kuriyan, J. (2006) A Src-like inactive conformation in the abl tyrosine kinase domain, PLoS Biol.

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Kinase Inhibitors: Methods and Protocols by Doriano Fabbro, Sandra W. Cowan-Jacob, Henrik Möbitz (auth.), Bernhard Kuster (eds.)

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