Download PDF by Dr. Graham Basten: Introduction to Clinical Biochemistry

By Dr. Graham Basten

ISBN-10: 8776816737

ISBN-13: 9788776816735

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In competitive inhibition the inhibitor is very similar to the substrate and competes for the site binding site, like fake plastic toast (inhibitor) will fit in the same slot as the bread (substrate). Thus, the more competitor you have the more likely that inhibition will occur. In non-competitive inhibition the inhibitor binds at a different site on the enzyme to that of the substrate, once bound the inhibitor changes the shape of the substrate site thus preventing the substrate from binding. These two options allow the body to regulate its processes via negative feedback using a allosteric inhibition.

Either of these events will result in the inflammation trilogy driven by tissue injury caused by the patient’s own white blood cells. com 39 Introduction to Clinical Biochemistry: Interpreting Blood Results Autoimmune and inflammation So, to begin with most autoimmune disease, at level one, will have a raised WBC, increased neutrophil differential, CRP, PV and ESR. The next step is to differentiate between the different types of autoimmune disease. At this stage the blood tests will be used along with patient history and examination, for example ankylosing spondylitis (AS) will be primarily seen in the patient’s back, whilst rheumatoid arthritis (RA) is more likely in digits.

3. Production: The liver also produces some of the chemicals we have already discussed like CRP, fibrinogen and transferrin. Please click the advert Start to link the tests and key concepts learnt so far. Example, why would a patient with RA being treated with a drug, also have her LFTs measured? 1: Each one of the liver tests provides “geographical” information. Bilirubin is more indicative of the “plumbing” to (pre) and from (post) the liver. The enzymes ALT, AST and GGT are mainly found inside the liver whilst ALP is more indicative of damage to the biliary tree (bile duct etc).

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Introduction to Clinical Biochemistry by Dr. Graham Basten


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