Intraperitoneal Cancer Therapy (Current Clinical Oncology) by C. William Helm, Robert Edwards PDF

By C. William Helm, Robert Edwards

ISBN-10: 1588298787

ISBN-13: 9781588298782

ISBN-10: 1597451959

ISBN-13: 9781597451956

Intraperitoneal melanoma treatment investigates intraperitoneal chemotherapy in quite a few advanced and engaging methods. the quantity info significant medical trails up to now, together with immunotherapy, hyperthermic remedy of colo-rectal and ovarian cancers. Authors additionally research neighborhood techniques to remedy, systemic treatment, and using carboplatin and paclitaxel because the typical therapy for girls with phases III and IV ovarian melanoma. different chapters additionally examine suggestions and methods in remedy, in addition to the longer term course of either normothermic and hyperthermic intraperitoneal chemotherapy.

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Sample text

For each woman is 3%. 13, respectively, but these data are only reported in two trials. 99), but this conclusion is based on the post hoc combination of tinnitus and hearing loss after multiple comparisons. Consequently, this apparent advantage to the IP route should be treated with caution. Pulmonary, alopecia, metabolic, pain, lymphatic, and hepatic adverse effects were only reported in two or less studies, and the data are heterogeneous. Catheter problems are described in most studies. 7%) (8).

Rather, the aim should be to attain a systemic drug concentration that permits sufficient delivery of the platinum agent to the tumor by capillary flow, as previously defined in phase III randomized clinical trials (26–29). indd 15 5/9/2007 2:02:24 PM 16 Markman 5. EVALUATION OF THE BIOLOGICAL ACTIVITY OF IP CYTOTOXIC CHEMOTHERAPY IN THE MANAGEMENT OF OVARIAN CANCER After the completion of phase I studies, which defined the pharmacokinetic properties and safety of both single-agent and several combination chemotherapy IP programs, investigators in several centers and cooperative groups initiated a series of platinum-based phase II IP efficacy trials in patients with ovarian cancer (24,30–40).

The survival curve depicted in this report is a simple summation of the data and is reproduced to provide a pictorial illustration (Fig. 1). Adverse effects of therapy were abstracted. We elected to classify toxicity as severe if it was graded 3 or more. If necessary, different categories of toxicity were combined within trials to facilitate pooling of data from different trials. For example, different authors described ototoxicity differently. Armstrong’s paper focused on grade 3 and 4 tinnitus, whereas Kirmani focused on hearing loss.

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Intraperitoneal Cancer Therapy (Current Clinical Oncology) by C. William Helm, Robert Edwards


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