By B. Abdel-Salam
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Additional info for Histocompatibility
1999). However, it still remains to be clarified if this polymorphism has any impact on the expression of certain HLA-G alleles. 2 3’untraslated region (UTR) The exon 7 of the HLA-G locus is always absent in the mature messenger(m)RNA. Moreover, due to the presence of a stop codon in the exon 6 of HLA-G, the exon 8 is not translated. Thus, exon 8 is considered the 3’ UTR of the mature RNA. , 2009), and several polymorphic sites that may potentially influence mRNA stability, turnover, mobility and splicing pattern.
2004). , 2007b). , 2007b). , 2008). , 2010). DC10 are characterized by the outstanding ability to produce IL-10 and by the expression of high levels of membrane-bound HLA-G1 and other tolerogenic signaling molecules such as ILT2, ILT3, and ILT4 (Fig. 3). , 2010). , 2010). , 2011). 5. HLA-G expressing regulatory cells In addition to myeloid cells that can constitutively or transiently express HLA-G, T cells or other immune cells can express or secrete HLA-G. , 2007). They represent a small subset of peripheral blood cells in healthy individuals, but 26 Histocompatibility Fig.
Immunology 126, 436-445. , and Moreau, P. (2011). Implications of the polymorphism of HLA-G on its function, regulation, evolution and disease association. Cell Mol Life Sci 68, 369-395. , and Pena, J. (2011). Emerging topics and new perspectives on HLA-G. Cell Mol Life Sci 68, 433-451. D. (2010). ILT2/HLA-G interaction impairs NK-cell functions through the inhibition of the late but not the early events of the NK-cell activating synapse. FASEB J 24, 689-699. , and Wiendl, H. (2007). HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation.
Histocompatibility by B. Abdel-Salam