By David Gozzard, David Warwick
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Extra info for Handbook of Thromboprophylaxis, 2nd Edition
Trousseau correctly diagnosed it in himself scarcely 18 months later and died of stomach cancer in 1867 . Pathophysiology Mucinous adenocarcinomas secrete abnormally glycosylated mucins and mucin fragments into the bloodstream . Such tumours, grown in tissue culture, produce a supernatant that is tumour-free but characteristically shows marked thrombogenic properties. It is this secretion of abnormal mucins that leads to the hypercoagulable state in some malignancies and the association with VTE.
3. Wahrenbrock M, Borsig L, Le D, et al. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest 2003; 112:853–862. 4. Sack GH Jr, Levin J, Bell WR. Trousseau’s syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical pathophysiologic, and therapeutic features. Medicine (Baltimore) 1977; 56:1–37. #FMM83
FUBM5SPVTTFBVTTZOESPNF%FWBTUBUJOHDPBHVMPQBUIZJOUIF absence of heparin.
26. Durica S, Raskob G, Johnson C, et al. Incidence of deep-vein thrombosis after arthroscopic knee surgery. Thromb Haemost 1997; 77(Suppl):183. +BVSFHVJUP+8
FUBM5IFJODJEFODFPGEFFQWFOPVTUISPNCPTJTBGUFS arthroscopic knee surgery. Am J Sports Med 1999; 27:707–710. 28. Michot M, Conen D, Holtz D, et al. Prevention of deep-vein thrombosis in ambulatory arthroscopic knee surgery: a randomized trial of prophylaxis with low-molecular weight heparin. Arthroscopy 2002; 18:257–263.
Handbook of Thromboprophylaxis, 2nd Edition by David Gozzard, David Warwick