Download e-book for kindle: Current topics in bioenergetics. V.14, 1985 by C. P. Lee

By C. P. Lee

ISBN-10: 0121525147

ISBN-13: 9780121525149

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U p to now, this methodology requires a tunable X-ray source with high ñux such as exists at a synchrotron faciUty; nevertheless, precise structural information regarding the location of the " h e a v y " atom can be obtained. , chlorine, bromine, and iodine. To a first approximation, perturbations of the membrane structure by the " h e a v y " atom labeled drugs should be similar since the size of the "perturbant" is similar so that the changes in electron density can be attributed to the label's location in the unit cell profile structure.

Conclusions X-Ray and neutron diffraction can be powerful tools for defining the precise interaction of small molecules with model and biological mem­ branes. When combined with other methodologies, these tools can pro­ vide valuable information for defining the molecular mechanism of this interaction.

Thus, for heavy atom labeled molecules in membrane bilayers in ratios up to this limit range, it should be possible to measure changes in the scatter­ ing function so long as the sources of perturbations to the electron density profile structure can be identified as discussed above. C. A P P L I C A T I O N S TO D R U G - M E M B R A N E S T U D I E S The above calculations for a Hg-labeled small molecule could also apply to other heavy atoms such as I, CI, Br, and Fe. This approach can become quite valuable for defining the location of drug molecules in mem- 42 L E O G.

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Current topics in bioenergetics. V.14, 1985 by C. P. Lee


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