Download e-book for kindle: Cell and Molecular Biology of Endometrial Carcinoma by Hiroyuki Kuramoto, Mieko Hamano, Manami Imai, Takesi

By Hiroyuki Kuramoto, Mieko Hamano, Manami Imai, Takesi Fujisawa, Yuko Kamata (auth.), Hiroyuki Kuramoto M.D., Ph.D., Masato Nishida M.D., Ph.D. (eds.)

ISBN-10: 4431539816

ISBN-13: 9784431539810

ISBN-10: 4431679774

ISBN-13: 9784431679776

The fifteenth overseas Symposium of the Japan Human cellphone Society on phone and Molecular Biology of Endometrial Carcinoma introduced jointly major researchers from Japan and around the globe. The papers accrued listed here are the paintings of 22 leaders of their box and are prepared in ten significant different types. the 1st part, in vitro experimental platforms, takes up the pioneering paintings by means of Kuramoto in 1968 and Nishida in 1980 in developing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma phone strains. different subject matters comprise apoptosis, proliferation, and development components; mobilephone cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. offering the most recent paintings within the telephone and molecular biology of endometrial carcinoma, this quantity is a beneficial source for gynecologists, pathologists, and molecular biologists.

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Extra resources for Cell and Molecular Biology of Endometrial Carcinoma

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Watanabe J,Sato H, Kanai T et al. (2002) Paradoxieal expression of cell cyele inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus . Br J Cancer 87:81-85 118. Alkhalaf M, Murphy LJ, Murphy LC (1993) Enhanced c-jun activity alters responsiveness to medroxyprogesterone acetate in Ishikawa human endometrial carcinoma cells. Mol Endocrinol 7:1634-1641 119. Chin T, Parry RL,Donahoe PK (1991) Human Müllerian inhibiting substance inhibits tumor growth in vitro and in vivo. Cancer Res 51:2101-2106 120.

Biochem Cell Biol 74:875-886 124. Tan MI, Strunk E, Scholzen T et al. (1999) Extracellular matrix regulates steady-state mRNA levels of proliferation associated protein Ki-67 in endometrial cancer cells. Cancer Lett 140:145-152 125. Park D, Ryu H, Choi D et al. (2001) Localization of matrix metalloproteinases on endometrial cancer cell invasion in vitro . Gynecol Oncol 82:442-449 126. Sillem M, Prifti S, Koumouridis A et al. (1999) Invasiveness corresponds to differentiation rather than to proteinase secretion in endometrial cancer cell lines.

The PTEN gene encodes a multifunction al phosphatase that plays an important role in inh ibiting the PI3-K pathway and downstream functions that ineIude activation of AKT/PKB, cell sur vival and cell proliferation. AKT, of which PTEN is the negative regulator, is elevated in Ishikawa cells with a mutant PTEN gene, whereas in HEC-I-A cells with a wild-type PTEN gene AKT levels were not elevated [114,115]. Lilja et aI. [11 5] reported that expression of PTEN significantly suppressed the growth of Ishikawa cells when the cells were transfected with wild-type PTEN cDNA, but not when ceIls had been transfected with mutant PTEN (CI24S).

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Cell and Molecular Biology of Endometrial Carcinoma by Hiroyuki Kuramoto, Mieko Hamano, Manami Imai, Takesi Fujisawa, Yuko Kamata (auth.), Hiroyuki Kuramoto M.D., Ph.D., Masato Nishida M.D., Ph.D. (eds.)


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