By Thomas Aigner, Zhiyong Fan (auth.), Christian Hendrich M.D., Ulrich Nöth M.D., Jochen Eulert M.D. (eds.)
The reconstruction of articular cartilage defects continues to be one of many significant demanding situations for the orthopaedic doctor. various surgical suggestions reminiscent of microfracturing, transplantation of osteochondral grafts and the autologeous chondrocyte transplantation were built over the past a long time. contemporary growth in fabric technological know-how and mobilephone and tissue engineering has enable to a world expanding variety of scientists engaged on cell-based articular cartilage fix suggestions. In a workshop symposium held in Würzburg, Germany, in November 2002 best scientists from biomedical engineering, uncomplicated technological know-how and really expert surgeons mentioned the cutting-edge in "Cartilage surgical procedure and destiny Perspectives".
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Additional info for Cartilage Surgery and Future Perspectives
Fuller JA, Ghadially FN (1972) Ultrastructural observations on surgically produced partialthickness defects in articular cartilage. Clin Orthop 86:193-205 13. Fuss M, Ehlers EM et al. (2000) Characteristics of human chondrocytes, osteoblasts and fibroblasts seeded onto a type IIIII collagen sponge under different culture conditions. A light scanning and transmission electron microscopy study. Anat Ann 182:303-310 14. Goymann V (1999) Abrasion arthroplasty. Orthopade 28:11-18 15. Grande DA,Pitman MI, Peterson L, Menche D, Klein M (1989) The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantaion.
Saline is gently injected underneath the periosteal flap to check for leakage between the flap and the cartilage rim. If no leakage can be detected the saline is aspirated and the chondrocytes in sus- Autologous Chondrocyte Transplantation - Long-Term Results pension are injected to fill the defect completely. The last opening is closed and the wound is sutured in layers [7,9,10] (Fig. 1). Osteochondral Lesions When treating a shallow osteochondral lesion with a bony defect no deeper than 6 to 8 mm the sclerotic bottom of the bony defect is debrided, again very carefully so no bleeding is caused .
The future goal is tissue engineering with mesenchymal stem cells and minimal invasive technologies for a faster rehabilitation and good long-term results in the therapy of articular cartilage repair. References 1. Aigner T, Gluckert K, Mark K (1997) Activation of fibrillar collagen synthesis and phenotypic modulation of chondrocytes in early human osteoarthritic cartilage lesions. Osteoarthritis Cartilage 5:183-185 2. Bachmann G, Heinrichs C, Jurgensen I, Rominger M, Scheiter A, Rau WS (1997) Comparison of different MRT techniques in the diagnosis of degenerative cartilage diseases.
Cartilage Surgery and Future Perspectives by Thomas Aigner, Zhiyong Fan (auth.), Christian Hendrich M.D., Ulrich Nöth M.D., Jochen Eulert M.D. (eds.)