By N.N. Sukhareva-Buell
The look for new manufacturers of biologically energetic ingredients (BAS) opposed to human and animal ailments remains to be a big activity in biology and drugs. Experimental paintings needs to be performed good ahead of desire since it takes a regular of ten years to boost a brand new medicine, in addition to time beyond regulation to place it out there. research of the Protozoa varieties a distinct department of biology - protozoology. the normal fields of protozoology are taxonomy, phylogeny, morphology, cytology, evolution, ecology and host parasite-interactions. The Protozoa is the one taxon one of the microscopic organisms, which has no longer been repeatedly studied as a resource of BAS. This ebook then is the results of the study at the undertaking: "Biologically lively ingredients of the Mastigophora (Flagellates)". The examine was once performed on the Laboratory of Antibiotics, division of Microbiology, organic school of Moscow nation collage. Articles of different authors at the topic were regarded as the $64000 a part of this reference ebook. The objective of the reference e-book is to explain clinical techniques, which result in acquiring biologically energetic ingredients from cultures of protozoa; the publication experiences the ancient history in reference to modern improvement of the sphere. N.N. Sukhareva ACKNOWLEDGMENTS The learn was once played in fruitful cooperation with my study affiliates (V. Urinyuk, T. Titiova, L. Udalova, R. Zeleneva, V. Brusovanik, M. Zaretskaya), postgraduate scholars (N. Kalenik, M. Chuenkova, V. Vasilevskaya, V. Khorokhorina), my colleagues at Moscow nation collage (Yu. Kozlov and I.
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Additional info for Biologically Active Substances of Protozoa
Biosynthesis of polyunsaturated fatty acids (PUFAs) is a characteristic feature of flagellates. , 1962). , 2001) . It leads to the formation of linoleate and (X- linolenate. Higher animals cannot synthesize linoleate from oleate. , 1972 Sprecher, 2000) . Nonphotosynthetic protozoa can transform oleate into linoleate . , 1981). Among phytoflagellates, there are organisms which possess a wide range of inducible enzymes . These organisms are capable of using both pathways for unsaturated fatty acid biosynthesis.
Acyltransferase activity is associated with membrane-rich subcellular fractions of T. b. brucei. This enzyme is different from acyltransferases of mamma ls by its preference for oleoyl-CoA and myristoyl-CoA, whereas the mammalian enzymes show a preference for arachidonyl-CoA; the trypanosomal and mammalian enzymes differ by their sensitivity to the hydrophobic calcium ionophore A23187 and to benzyl alcohol. The acyltransferase activity of T. b. brucei is high if exogenous acyl-coenzyme A and exogenous Iysophospholipids are available .
One of these dehydrogenases converts stearateACP but not stearate-CoA (Nagai and Bloch, 1965). Biosynthesis of polyunsaturated fatty acids (PUFAs) is a characteristic feature of flagellates. , 1962). , 2001) . It leads to the formation of linoleate and (X- linolenate. Higher animals cannot synthesize linoleate from oleate. , 1972 Sprecher, 2000) . Nonphotosynthetic protozoa can transform oleate into linoleate . , 1981). Among phytoflagellates, there are organisms which possess a wide range of inducible enzymes .
Biologically Active Substances of Protozoa by N.N. Sukhareva-Buell