By Magnus Rueping, Dixit Parmar, Erli Sugiono
A much-needed evaluation of the synthesis of chiral Brønsted acids and their purposes in numerous natural variations.
The across the world famous and hugely revered specialist authors summarize the main major advances during this new and dynamically progressing box, with a different emphasis on BINOL-derived phosphoric acids. in addition they describe different catalysts, comparable to C-H, TADDOL-derived Brønsted, and sulfonic acids. for simple navigation, the chapters are geared up within the first example based on reactive intermediate after which sub-divided by means of response type.
An appendix with chosen experimental information for benign and straight-forward systems rounds of the ebook, making this the number-one info resource for natural chemists in academia and undefined.
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Additional info for Asymmetric Bronsted Acid Catalysis
46) . Noteworthy was the fact that N–H-free pyrroles yielded the desired products but with almost no enantioselectivity. This result suggests that coordination of the pyrrole partner must compete comparatively with a pathway involving no coordination. The groups of Nakamura , You , Ishihara , and Jiang and Zhang  have also shown the use of pyrroles and dihydroindoles in similar transformations. 46 Friedel–Crafts reaction of non-indole aromatics by Antilla . 47) .
31) . 31 Strecker reaction by Dughera . 32 Mechanism of the Strecker reaction . to the catalyst . 32. As predicted by computational calculations, the catalyst is involved in hydrogen bonding to both the imine and cyanide moieties. Closely related works by the groups 29 30 2 Reactions of Imines of Tsogoeva  and Ma  have also been reported using phosphoric acid catalysts. The major drawback of the Strecker reaction lies in the handling of toxic cyanide sources, which must be handled with extreme precautions.
O H P OCHEt2 OCHEt2 23 24 2 Reactions of Imines product is formed. Related transformations have been studied by the groups of Lin  and Song  using chiral phosphoric acids. 2 Mannich Reactions The Mannich reaction is now considered as the benchmark asymmetric transformation, which can be catalyzed by a plethora of organocatalysts. It is frequently used by research groups as the testing ground in the development of new catalysts. It is also famously known as the protocol, which kick-started the ﬁeld of chiral Brønsted acids.
Asymmetric Bronsted Acid Catalysis by Magnus Rueping, Dixit Parmar, Erli Sugiono